Hi @hopefulone ,
@ThomasTu, you amaze with how much you know and that you willingly share. I wish my hepatologist would offer more free advice.
Yes, it is true that some medications oddly cannot be administered near time grapefruit/ grapefruit juice are consumed. One example are the cholesterol lowering meds such as the “statins” such as atorvastatin (Lipitor) and simvastatin (Zocor).
From FDA website:
With most drugs that are affected by grapefruit juice, “the juice lets more of the drug enter the blood,” says Shiew Mei Huang, Ph.D., of the FDA. “When there is too much drug in the blood, you may have more side effects.”
For example, if you drink a lot of grapefruit juice while taking certain statin drugs to lower cholesterol, too much of the drug may stay in your body, increasing your risk for liver and muscle damage that can lead to kidney failure.
Many drugs are broken down (metabolized) with the help of a vital enzyme called CYP3A4 in the small intestine. Grapefruit juice can block the action of intestinal CYP3A4, so instead of being metabolized, more of the drug enters the blood and stays in the body longer. The result: too much drug in your body.
This website has video which I will include in case anyone is interested.
Grapefruit Juice and Some Drugs Don't Mix | FDA.
Sorry for this delayed response. I have not been active this year as someone in US the last year of high school/preparing for college is a really chaotic and hectic time for not only the student but the parents 