Dear @CSKAY,
I’ve moved your question into this thread about cure (please feel free to read the other responses to get a broader idea about what’s going on in this area). To answer your questions:
- The clearance of cccDNA from the liver is the definition of “complete cure”. We have made a video of it here: What do we mean by Hepatitis B cure? - HBV Cure FAQs
- Also explained in the video above.
- Explained in these video here: How possible is a cure for Hepatitis B? - HBV Cure FAQs; What could a Hepatitis B cure look like? - HBV Cure FAQs; What do we need to achieve a Hepatitis B Cure? - HBV Cure FAQs. Essentially, we are closer towards a cure, but I think having one ready and available to people within 5 years is going to be tricky and require a lot of investment in the area.
- Again, explained in the videos above. More than likely, the first few approaches to cure are going to require combinations of drugs.
- There are quite a few coming up: Hepatitis B Foundation: Drug Watch
Hope these help,
Thomas