New Drugs to cure Hep B?

[bob]

Not sure where to put this but I always found this particularly fascinating but it’s been archived so I can’t reply there:

Example entry: Hepatitis B cccDNA viral reservoirs - stubborn nails in the quest for a complete cure

Hi all! I’m a PhD student under @ThomasTu working on a few projects revolving around cccDNA, which I’m sure you all know about. Briefly - cccDNA is a stable form of Hepatitis B Virus, which stays in liver cells and is a blueprint which the virus uses to make new virus particles. Getting rid of it is the tricky bit because current drugs (e.g. entecavir, tenofovir, lamivudine) don’t target this form of HBV, only the creation of new virus part of the life cycle. One way which the body naturally ge…

May I ask if there is any updates on this, or papers released or anything?