EXPLAINER: Lab results and their interpretation

Just to add these are my random LFT and viral loads between both of the extended reports and also I have done a CT sac an that examination report I will put in as well I felt a bit of heaviness on the right side so the doctor referred me to do it also three ULTRASOUND have been performed two in Switzerland one in Poland doctors said all in order. Reports are in German but translation can be done easily.

Please do anyone or everyone have a look at these and reports in my last post to give me their view on this.

Cheers
Rana



Dear @marian,

It’s unclear what specifically you want to know about your status, your blood results don’t seem to have changed in that time.

Dear @Gourav_Rana,

Your HDV antibody appears to be positive, so it would be worthwhile getting a HDV RNA test to see if you also have HDV infection. Indeed, it is a good idea to do a fibroscan/ultrasound assessment to get an idea of your liver health, particularly given your higher than normal ALT markers.

Hope this helps,
Thomas

1 Like

Hi @ThomasTu

Yes indeed my doctor did the test for D RNA which came out negative I mean no viral load as it is now a days mandatory to test all for D which turns out positive for hepB. All my labs and Ultrasound were fine and latest HBV DNA is 56 in/ml which was almost 19000000 3 months earlier.

I have no clue either it was my doctors funny machine with which the same he performed ultrasound plus he measured elasticity of my liver which was last time 7 kph and now just in hardly 2 months time turned 10 kpa with me being on good diet and having to have Vemlidy daily.

Rest turned out fine ALT was around 60 but had settle down in test I’ve done couple of time before. Don’t know hu it spiked but rest looked in order, ultrasound was fine even had a CT scan which was fine too all in order.
Do let me know what do you think about these changes in my KPA.

Many thanks
Rana

Hi @Gourav_Rana,

I am unable to comment about the elastography, but it seems like all other indicators of your liver health are in normal range and that it is worthwhile to keep under monitoring to see if it is an ongoing issue.

Thomas

1 Like

Dear @ThomasTu

Thanks for the message.

Yeah I have been closely monitoring everything and as I mentioned even got a CT scan done just 2 weeks before that Ultrasound and so called elasticity that my hepatologist measured. In the CT scan reports came out all normal and also since the last time I did my ultrasound and the doctor (same doctor) gave me the reading of 7 KPA and I did nothing unusual during all this time yeah maybe a pizza or two :tipping_hand_man:t4::man_shrugging:t4: but I guess if that caused it then I don’t think I am a normal human :man_facepalming:t4: if you see what I mean.
Hopefully it might be just a faulty report or if it’s right then I am a bit worried and it keep me up in nights just that number. Though my doctor said don’t worry all in order Vemlidy does it work but in a longer run just make sure you keep taking it and don’t miss a day. Which I have been doing ever since even before that since he put me on meds.
I’ll be having my LFT done soon. Hoping to have the virus TND this time rest I will keep the group posted.
Let me know of any suggestions.

Cheers
Rana

1 Like

Hi everyone please kindly help me review my Lab work and make some suggestions please
1 .FASTING lipids profile

Total cholesterol - 186mg/dl
Triglycerides - 82mg/dl

HDL - 79mg/dl
LDL-101 mg/dl
VLDL-6mg/dl

  1. SEROLOGY

Anti HBc total 0.4 index value

HBeAb( anti-HBe) - 0.2 index value

HbeAg -0.4 index value

HBsAg (ELISA)- 2.5 index value

HBsAb( anti-HBe ELISA)

  1. VIRAL DNA test
    HBV DNA quantitative real time PCR --117 IU/ml

Log 10 HBV DNA load - 2.1

Please kindly help me review do you think i need a treatment

4 liver ultrasound
Liver span 17cm

Grade 1 fatty liver desaes was only placed on vitamin E by my gastroenterologist
He said my HBV infection is under control
Suggestions please

If your doctor said it was under control I don’t know why you’d wanna doubt him.

@GreyhoundTJX
It’s not about doubting my doctor but it’s about seeking for different opinion
You can genuinely give your own opinion
And not make it feel as if someone is doubting his/her doctor

Most people who posted their Lab investigation here are seeing one doctor or the other
Having a 2nd opinion is not a bad idea please

Hello @Sent-d
I can’t answer your medical questions but someone will soon.
This forum is great for learning about our disease and discussing issues we don’t feel comfortable with in our local communities.

1 Like

Thanks so much for your response really appreciate

Dear @Sent-d,

Under current EASL guidelines, you would not be recommended for treatment due to low viral load.

Hope this helps,
Thomas

1 Like

Thanks so much for your response really appreciate @ThomasTu
Please kindly help me with the EASL guideline please

Dear @Sent-d,

The EASL guidelines can be found here: https://easl.eu/wp-content/uploads/2018/10/HepB-English-report.pdf

Thomas

Thanks so much for the information

1 Like

Hi Thomas, I followed up on these labs with a liver specialist. On repeat, I tested negative for HepBe antigen test and negative for all antibodies. They decided I do not have HepB but based on the discrepancy in antibody testing, I can proceed as if I had it at some point and cleared it. Great news!

1 Like

Fantastic news, @Holly, thanks for letting us all know and I’m glad you can live a bit easier now.

If you are still negative for anti-HBs antibodies, then it is still worthwhile to get the vaccination for peace of mind and to know that you’d be protected should you ever be exposed in the future.

Cheers,
Thomas

1 Like

Hi All,

I am a 42 years old male in US. A couple months ago, I was tested positive for HBsAg during my annual exam and was asked to see a infectious disease doctor. This was a shocker to me.

I was raised in a country where HepB is common. So this might have something to do with the test results.

Long story short, I did the follow up with the doc and received the following test results.

ALT (SGPT) - 31
HBV IU/mL < 10 (HBV DNA detected)
HBsAb Quant HBIG Assessment - 7.5
Hep B Core Ab, Tot - Positive
Hep B Core Ab, IgM - Negative
HBsAg Screen - Positive
Hep Be Ag - Negative
Hep Be Ab - Positive

I have follow up scheduled with the doc in 3 weeks and also have a liver ultrasound coming up next week.

I am curious to see what these test results mean as I still have three weeks before the next appointment.

I live a healthy life style and have had no symptoms of illness.

Thank you so much for all the support!

Hi @brnie80,

I’ll leave the full explanation of your test results to the experts, but I need to learn this stuff so I will try to interpret the results as long as you understand that I am not a science or health expert and do not work in either fields. However, I do need to learn how to interpret results better, so I am going to do my best with yours and let the experts ‘help’ me where I go wrong and supplement where there needs further explanation. So please bear with me on this:

ALT (SGPT) – 31 = lanine Aminotransferase is an enzyme that is a marker for liver cell damage. Yours looks to be within range.
HBV IU/mL < 10 (HBV DNA detected) = Your viral load is undetectable and that’s a great thing.
HBsAb Quant HBIG Assessment - 7.5 = Here is the definition for this but I have no idea how this relates to you, so experts will need to explain this one. Hepatitis B Immune Globulin (HBIG): A medication that is given as a “post-exposure” treatment to prevent hepatitis B. This means that HBIG is given after a person has been exposed to potentially infected blood or infected bodily fluids, which can include but is not limited to - contact with blood or through a needle-stick, infants born to infected women, and through sexual contact or close household contact with an infected person. HBIG is often used as a post-liver transplant treatment.
Hep B Core Ab, Tot – Positive = This is only a signifier that you may have been exposed to the HBV virus. This needs to be confirmed by the two tests, HBsAg and HBsAb
Hep B Core Ab, IgM – Negative = This is only positive if your infection was recent (6 months).
HBsAg Screen – Positive = This confirms that the Hep B virus is present.
Hep Be Ag – Negative = A positive result would mean that you have a high factor of viral replication, so it’s good that it is negative.
Hep Be Ab – Positive = I could not find this one in our list of definitions, so I looked it up elsewhere and it says: “The HBeAg test is to screen the presence of hepatitis B antibodies. This test is helpful in the detection of active hepatitis B infection. Hence, this test is useful in patients diagnosed with hepatitis B infection to identify if they have an active infection. This test is done in conjunction with the hepatitis Be Antigen test. In case of any active infection, levels of hepatitis B antigens will be high and adverse for Be antibodies. After successful treatment, the hepatitis Be antigen test will be negative and the hepatitis B antibodies test will be positive. Those with latent hepatitis must undergo the HbeAb test at least twice a year. This helps in the early identification of the reactivation of the virus.” - @ThomasTu, Does this mean he has been successfully treated then?

I was initially responding to you to welcome you to the community and say I am glad you found your way here. However, I need practice in basic interpretation of test results, so I took this opportunity. Again, let me reiterate, I am not a member of the medical or science community. So keep in mind that this is basic interpretation and the experts know what all these test results mean in correlation to each other.

I’m glad that you found this community and as a non-expert, these results seem pretty good to me.

-Paul

1 Like

Dear @brnie80,

Welcome to the forum and glad you found us. Thanks for the questions.

Re: your lab results, these are consistent with a well-controlled infection, with very low viral levels and no ongoing liver. People with these results are generally quite stable and do not progress to liver disease. Essentially this is good news!

Hope this helps,
Thomas